Q:What are the most common birth defects?
Cleft lip/palate and Down syndrome are among the most common birth defects in the United States (7). About 6,800 babies are born with cleft lip/palate each year (7). Cleft lip/palate can cause problems with eating, speech and language. Some affected babies have a small cleft that can be corrected with one surgical procedure, while others have severe clefts and need multiple surgeries. About 5,500 babies are born each year with Down syndrome (7). About 1,900 babies are born with a serious heart defect called transposition of the great arteries each year (7). Many more babies are born with other serious heart defects. While advances in surgery have dramatically improved the outlook for affected babies, heart defects remain the leading cause of birth defect-related infant deaths (8). Health care providers usually do not know what causes a baby's heart to form abnormally, although both genetic and environmental factors play a role. Spina bifida (open spine) occurs in about 1,300 babies each year (9). Affected babies have varying degrees of paralysis and bladder and bowel problems. Both genetic and environmental factors (including insufficient amounts of a vitamin called folic acid) appear to play a role. Other common birth defects include musculoskeletal defects (including arm and leg defects), gastrointestinal defects (including defects of the esophagus, stomach and intestines) and eye defects (7). These birth defects usually are multi-factorial. WEBSITE
Q: What is my chance of having a baby with a birth defect?
In the United States, about 3% of babies are born with birth defects. Some women have a higher chance of having a child with a birth defect. Women over the age of 35 years have a higher chance of having a child with Down syndrome than women who are younger. If taken when a woman is pregnant, certain drugs can increase the chance of birth defects. Also, women who smoke and use alcohol while pregnant have a higher risk of having a baby with certain birth defects. Other women have a higher chance of having a baby with a birth defect because someone in their family had a similar birth defect. To learn more about your risk of having a baby with a birth defect, you can talk with a genetic counselor. (To find a genetic counselor, see Where can I find a geneticist or genetic counselor?) Also, to reduce your chances of having a baby with a birth defect, talk with your health care provider about any medicines that you take, do not drink alcohol or smoke, and be sure to take 400 micrograms of the B vitamin folic acid every day. It is the amount of folic acid found in most multivitamins. WEBSITE
Q: How to decreasing the chances of birth defects?
Of the 4 million infants born annually in the United States, about 3 to 5 percent are born with birth defects, according to the March of Dimes. Birth defects account for 20 percent of all infant deaths in the United States, more than from any other single cause.
"For the majority of birth defects, the cause is unknown," says Franz Rosa, M.D., a pediatrician, formerly with the Food and Drug Administration, who monitored reports of prescription drugs causing birth defects. Rosa cites a list of drugs that are known to be birth-defect causing, but he says they only account for a small percentage of all malformations.
"There's a lot we just don't know," Rosa says. "Most birth defects are not preventable and mothers should not feel guilty about causing defects that they really didn't. Worrying too much is not good for pregnancies."
What experts do know is that most birth defects occur in the first three months of pregnancy, when the organs are forming. It is in these crucial first few weeks--often before a woman even knows she's pregnant--that an embryo is most susceptible to teratogens, substances that can cause defects. However, some birth defects do occur later in pregnancy as well.
"The key is what your life is like at the time you become pregnant," says Deborah Smith, M.D., an obstetrician and gynecologist in FDA's Office of Women's Health. "Are you getting enough folic acid, are you immune to rubella, are you avoiding alcohol and smoking? These are some of the things we know are important." WEBSITE
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